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Target
Fibroblast growth factor receptor 4 [388-802]
Ligand
BDBM209342
Substrate
n/a
Meas. Tech.
Biochemical Kinase Assay
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
0.3±n/a nM
Comments
extracted
Citation
 Buschmann, N; Fairhurst, RA; Furet, P; Knöpfel, T; Leblanc, C; Liao, L; Mah, R; Nimsgern, P; Ripoche, S; Xiong, J; Han, B; Wang, C; Zhao, X Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors US Patent  US9266883 Publication Date 2/23/2016 
Target
Name:
Fibroblast growth factor receptor 4 [388-802]
Synonyms:
FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor 4 (FGFR4) | JTK2 | TKF
Type:
Protein
Mol. Mass.:
45529.19
Organism:
Homo sapiens (Human)
Description:
GST-FGFR4(388-802)
Residue:
415
Sequence:
GLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM209342
Synonyms:
US9266883, 120
Type:
Small organic molecule
Emp. Form.:
C25H29N7O5
Mol. Mass.:
507.5417
SMILES:
COCCNc1cc(NC(=O)N2CCCc3cc(CN4[C@@H](C)COCC4=O)c(C=O)nc23)ncc1C#N |r|
Structure:
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