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Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM50316379
Substrate
n/a
Meas. Tech.
Spectrophotometrical Assay
pH
7.5±n/a
IC50
5000±300 nM
Comments
extracted
Citation
 Kantrowitz, ER; Heng, S Dibenzofuran derivatives as inhibitors of fructose 1,6-bisphosphatase and methods of use thereof US Patent  US9273021 Publication Date 3/1/2016 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
F16P1_PIG | FBP | FBP1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36781.07
Organism:
Sus scrofa (Pig)
Description:
Liver FBPase (P00636)
Residue:
338
Sequence:
MTDQAAFDTNIVTLTRFVMEEGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVSEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMVNGVNCFMLDPAIGEFILVDRDVKIKKKGSIYSINEGYAKEFDPAITEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFMYPANKKSPKGKLRLLYECNPMAYVMEKAGGLATTGKEAVLDIVPTDIHQRAPIILGSPEDVTELLEIYQKHAAK
  
Inhibitor
Name:
BDBM50316379
Synonyms:
1,1'-(1,3,7,9-Tetrahydroxydibenzofuran-2,6-diyl)bis(2-methylbutan-1-one) | CHEMBL1097227 | US9273021, 4
Type:
Small organic molecule
Emp. Form.:
C22H24O7
Mol. Mass.:
400.4218
SMILES:
CCC(C)C(=O)c1c(O)cc2oc3c(C(=O)C(C)CC)c(O)cc(O)c3c2c1O
Structure:
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