Reaction Details Report a problem with these data
Target
Reverse transcriptase protein
Ligand
BDBM1434
Substrate
n/a
Meas. Tech.
HIV-1 RT Inhibitory Assay
Temperature
298.15±n/a K
IC50
4.3e+3± 7e+2 nM
Comments
extracted
Citation
 Achuthan, V; Singh, K; DeStefano, JJ Physiological Mg(2+) Conditions Significantly Alter the Inhibition of HIV-1 and HIV-2 Reverse Transcriptases by Nucleoside and Non-Nucleoside Inhibitors in Vitro. Biochemistry 56:33-46 (2017) [PubMed]  Article 
Target
Name:
Reverse transcriptase protein
Synonyms:
Gag-Pol polyprotein | HIV-1 Reverse transcriptase (HIV-1 RT) | Reverse Transcriptase (HIV-1 RT) | Reverse transcriptase (HIV1-RT)
Type:
Protein
Mol. Mass.:
30197.77
Organism:
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)
Description:
Q9WJQ1
Residue:
259
Sequence:
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEEEGKISRIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKVEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQK
  
Inhibitor
Name:
BDBM1434
Synonyms:
11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2 ,3 -e][1,4]diazepin-6-one | 2-cyclopropyl-7-methyl-2,4,9,15-tetraazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-10-one | BI-RG-587 | CHEMBL57 | Nevirapine | Nevirapine (NVP) | US11420959, Example NVP | Viramune
Type:
Small organic molecule
Emp. Form.:
C15H14N4O
Mol. Mass.:
266.2979
SMILES:
Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12
Structure:
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