Reaction Details Report a problem with these data
Target
D-amino-acid oxidase
Ligand
BDBM50431069
Substrate
n/a
Meas. Tech.
In Vitro DAAO Enzyme Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
13±n/a nM
Comments
extracted
Citation
 Farnaby, W; Fieldhouse, C; Hazel, K; Kerr, C; Kinsella, N; Livermore, D; Merchant, K; Miller, D Pyridazinone compounds and their use as DAAO inhibitors US Patent  US9290456 Publication Date 3/22/2016 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM50431069
Synonyms:
CHEMBL2338795 | US10202399, Example 27 | US10463663, Example 7 | US11129828, Example 7 | US9212147, 27 | US9290456, 7 | US9931340, Example 7
Type:
Small organic molecule
Emp. Form.:
C12H11FN2O2
Mol. Mass.:
234.2263
SMILES:
Oc1cc(CCc2ccccc2F)n[nH]c1=O
Structure:
Search PDB for entries with ligand similarity: