Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM119403
Substrate
n/a
Meas. Tech.
Pim Kinase Binding Activity
pH
7.2±n/a
Temperature
298.15±n/a K
Ki
17.3±n/a nM
Comments
extracted
Citation
 Wang, X Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use US Patent  US9573943 Publication Date 2/21/2017 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM119403
Synonyms:
US8669361, 238 | US9573943, Example 238
Type:
Small organic molecule
Emp. Form.:
C22H23F3N6O
Mol. Mass.:
444.4528
SMILES:
Cn1ncc(NC(=O)c2ccc(F)c(n2)-c2c(F)cccc2F)c1N1CCC[C@@H](N)CC1 |r,wD:28.31,(-5.72,2.87,;-4.95,1.54,;-5.85,.29,;-4.95,-.96,;-3.48,-.48,;-2.15,-1.25,;-2.15,-2.79,;-3.48,-3.56,;-.82,-3.56,;-.82,-5.1,;.52,-5.87,;1.85,-5.1,;3.19,-5.87,;1.85,-3.56,;.52,-2.79,;3.19,-2.79,;3.19,-1.25,;1.85,-.48,;4.52,-.48,;5.85,-1.25,;5.85,-2.79,;4.52,-3.56,;4.52,-5.1,;-3.48,1.06,;-2.15,1.83,;-.76,1.16,;.63,1.83,;.97,3.33,;.01,4.54,;.78,5.87,;-1.53,4.54,;-2.49,3.33,)|
Structure:
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