Reaction Details Report a problem with these data
Target
Procathepsin L
Ligand
BDBM210842
Substrate
BDBM210882
Meas. Tech.
Cathepsin Enzyme Inhibition Assay
pH
6.5±n/a
IC50
878±n/a nM
Comments
extracted
Citation
 Anselm, L; Banner, D; Blanc, J; Gaufreteau, D; Haap, W; Hartmann, G; Kuhn, B; Luebbers, T; Peters, J; Spinnler, B Cyclic amides US Patent  US9290467 Publication Date 3/22/2016 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM210842
Synonyms:
US9290467, 12
Type:
Small organic molecule
Emp. Form.:
C23H27ClN4O3
Mol. Mass.:
442.938
SMILES:
Clc1cc2C[C@H](NC(=O)C3CCCN3CC\C=C\COc1cc2)C(=O)NC1(CC1)C#N |r,t:17|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM210882
Synonyms:
n/a
Type:
Small organic molecule
Emp. Form.:
C34H45N7O7
Mol. Mass.:
663.7638
SMILES:
[#6]-[#6](-[#6])-[#6@H](-[#7]-[#6](=O)-[#8]-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6](-[#6])-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-c1ccc2c(-[#6])cc(=O)oc2c1
Structure:
Search PDB for entries with ligand similarity: