Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM210937
Substrate
n/a
Meas. Tech.
CA Inhibition Assay
Ki
2.0±0.0 nM
Citation
 Bhatt, A; Mahon, BP; Cruzeiro, VW; Cornelio, B; Laronze-Cochard, M; Ceruso, M; Sapi, J; Rance, GA; Khlobystov, AN; Fontana, A; Roitberg, A; Supuran, CT; McKenna, R Structure-Activity Relationships of Benzenesulfonamide-Based Inhibitors towards Carbonic Anhydrase Isoform Specificity. Chembiochem 18:213-222 (2017) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM210937
Synonyms:
4-(3-formylphenyl)-benzenesulfonamide (4e)
Type:
Small organic molecule
Emp. Form.:
C13H11NO3S
Mol. Mass.:
261.296
SMILES:
NS(=O)(=O)c1ccc(cc1)-c1cccc(C=O)c1
Structure:
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