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Target
Neutrophil elastase
Ligand
BDBM211458
Substrate
BDBM211682
Meas. Tech.
Human Neutrophil Elastase Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
<1±n/a nM
Comments
extracted
Citation
 Peters, S; Anderskewitz, R; Morschhaeuser, G; Oost, T Substituted dihydropyrimidinones and their use as inhibitors of neutrophil elastase activity US Patent  US9290457 Publication Date 3/22/2016 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM211458
Synonyms:
US9290457, Example 1
Type:
Small organic molecule
Emp. Form.:
C23H19F3N4O3
Mol. Mass.:
456.4172
SMILES:
CN1C(C(C(C)=O)=C(C)N(C1=O)c1cccc(c1)C(F)(F)F)c1ccc(cc1C(N)=O)C#N |t:6|
Structure:
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Substrate
Name:
BDBM211682
Synonyms:
US9290457, MeOSuc-AAPV-AMC
Type:
Substrate
Emp. Form.:
C31H41N5O9
Mol. Mass.:
627.6853
SMILES:
COC(=O)CCC(=O)NC(C)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)Nc1ccc2c(C)cc(=O)oc2c1
Structure:
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