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Target5-lipoxygenase/FLAP
LigandBDBM160757
Substrate/Competitorn/a
Meas. Tech.FLAP Binding Assay
Ki 6.30±n/a nM
Citation Chai, WDeckhut, CDvorak, CAEccles, WEdwards, JPGoldberg, SDKrawczuk, PJLebsack, ADLiu, JTanis, VMTarantino, KT 1,2,5-Substituted benzimidazoles as flap modulators US Patent US9682971 Publication Date 6/20/2017
More Info.:Get all data from this article,  Assay Method
 
5-lipoxygenase/FLAP
Name:5-lipoxygenase/FLAP
Synonyms:5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | FLAP | MK-886-binding protein
Type:Enzyme
Mol. Mass.:18159.90
Organism:Homo sapiens (Human)
Description:P20292
Residue:161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNC
VDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIIL
FLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM160757
NameBDBM160757
Synonyms:US9682971, 41
TypeSmall organic molecule
Emp. Form.C32H27F4N3O4
Mol. Mass.593.5681
SMILESOC(=O)C1CCCCC1c1nc2cc(OCc3ccc4ccccc4n3)ccc2n1Cc1ccc(OC(F)(F)F)cc1F
Structure
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