Reaction Details Report a problem with these data
Target
Glycogen [starch] synthase, muscle
Ligand
BDBM212170
Substrate
n/a
Meas. Tech.
Glycogen Synthase Activity Assay
pH
7.3±n/a
Temperature
303.15±n/a K
EC50
270±n/a nM
Comments
extracted
Citation
 Nakagawa, T; Matsumoto, K; Takeshita, S; Yoshida, T; Tokumasu, M; Inoue, H; Kobayashi, K Pharmaceutical composition for treating diabetes US Patent  US9290487 Publication Date 3/22/2016 
Target
Name:
Glycogen [starch] synthase, muscle
Synonyms:
GYS | GYS1 | GYS1_HUMAN | Glycogen [starch] synthase, muscle | Glycogen synthase (GYS1) | Muscle glycogen synthase
Type:
Enzyme
Mol. Mass.:
83779.52
Organism:
Homo sapiens (Human)
Description:
P13807
Residue:
737
Sequence:
MPLNRTLSMSSLPGLEDWEDEFDLENAVLFEVAWEVANKVGGIYTVLQTKAKVTGDEWGDNYFLVGPYTEQGVRTQVELLEAPTPALKRTLDSMNSKGCKVYFGRWLIEGGPLVVLLDVGASAWALERWKGELWDTCNIGVPWYDREANDAVLFGFLTTWFLGEFLAQSEEKPHVVAHFHEWLAGVGLCLCRARRLPVATIFTTHATLLGRYLCAGAVDFYNNLENFNVDKEAGERQIYHRYCMERAAAHCAHVFTTVSQITAIEAQHLLKRKPDIVTPNGLNVKKFSAMHEFQNLHAQSKARIQEFVRGHFYGHLDFNLDKTLYFFIAGRYEFSNKGADVFLEALARLNYLLRVNGSEQTVVAFFIMPARTNNFNVETLKGQAVRKQLWDTANTVKEKFGRKLYESLLVGSLPDMNKMLDKEDFTMMKRAIFATQRQSFPPVCTHNMLDDSSDPILTTIRRIGLFNSSADRVKVIFHPEFLSSTSPLLPVDYEEFVRGCHLGVFPSYYEPWGYTPAECTVMGIPSISTNLSGFGCFMEEHIADPSAYGIYILDRRFRSLDDSCSQLTSFLYSFCQQSRRQRIIQRNRTERLSDLLDWKYLGRYYMSARHMALSKAFPEHFTYEPNEADAAQGYRYPRPASVPPSPSLSRHSSPHQSEDEEDPRNGPLEEDGERYDEDEEAAKDRRNIRAPEWPRRASCTSSTSGSKRNSVDTATSSSLSTPSEPLSPTSSLGEERN
  
Inhibitor
Name:
BDBM212170
Synonyms:
US9290487, compound of Ex. 17
Type:
Small organic molecule
Emp. Form.:
C27H21F2NO5
Mol. Mass.:
477.4561
SMILES:
OC(=O)[C@@H]1CCCN1C(=O)c1cccc(COc2ccc(cc2)-c2cc(F)c3occc3c2F)c1 |r|
Structure:
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