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Target
Tyrosine-protein kinase SYK
Ligand
BDBM212272
Substrate
n/a
Meas. Tech.
High Throughput Syk Biochemical Assay
pH
7±n/a
IC50
13.3±n/a nM
Comments
extracted
Citation
 Blomgren, PA; Currie, KS; Kropf, JE; Lee, SH; Lo, JR; Mitchell, SA; Schmitt, AC; Xiong, J; Xu, J; Zhao, Z; Swaminathan, S Substituted imidazo[1,2-a]pyrazines as Syk inhibitors US Patent  US9290505 Publication Date 3/22/2016 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM212272
Synonyms:
(R)-(4-(4-((6-(6-aminopyrazin-2-yl)imidazo[1,2-a]pyrazin-8-yl)amino)phenyl)morpholin-2-yl)methanol | US10342794, Example Ex.-3 | US10828299, Example Ex.-3 | US11517570, Example Ex.-3: | US9290505, Ex.-3 | US9504684, Ex.-3 | US9931338, Ex.-3
Type:
Small organic molecule
Emp. Form.:
C21H22N8O2
Mol. Mass.:
418.4518
SMILES:
Nc1cncc(n1)-c1cn2ccnc2c(Nc2ccc(cc2)N2CCO[C@@H](CO)C2)n1
Structure:
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