Reaction Details Report a problem with these data
Target
Coproheme decarboxylase
Ligand
BDBM51757
Substrate
n/a
Meas. Tech.
Fluorescence Titration Assay
pH
6.8±n/a
Kd
2210±100 nM
Comments
extracted
Citation
 Mayfield, JA; Hammer, ND; Kurker, RC; Chen, TK; Ojha, S; Skaar, EP; DuBois, JL The chlorite dismutase (HemQ) from Staphylococcus aureus has a redox-sensitive heme and is associated with the small colony variant phenotype. J Biol Chem 288:23488-504 (2013) [PubMed]  Article 
Target
Name:
Coproheme decarboxylase
Synonyms:
CHDC_STAAB | Chlorite dismutase (HemQ) | chdC
Type:
Protein
Mol. Mass.:
29320.74
Organism:
Staphylococcus aureus
Description:
Q2YS77
Residue:
250
Sequence:
MSQAAETLDGWYSLHLFYAVDWASLRLAPKDERDALVTELQSFLENTATVRSSKSGDQAIYNITGQKADLLLWFLRPEMKSLNHIENEFNKLRIADFLIPTYSYVSVIELSNYLAGKSDEDPYENPHIKARLYPELPHSDYICFYPMNKRRNETYNWYMLTMEERQKLMYDHGMIGRKYAGKIKQFITGSVGFDDFEWGVTLFSDDVLQFKKIVYEMRFDETTARYGEFGSFFVGHIINTNEFDQFFAIS
  
Inhibitor
Name:
BDBM51757
Synonyms:
3-[(1Z,4Z,9Z,15Z)-18-(2-Carboxy-ethyl)-3,7,12,17-tetramethyl-8,13-divinyl-porphyrin-2-yl]-propionic acid | 3-[18-(2-carboxyethyl)-3,7,12,17-tetramethyl-8,13-divinyl-22,23-dihydroporphin-2-yl]propionic acid | 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid | 3-[8,13-bis(ethenyl)-18-(3-hydroxy-3-oxopropyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid | CHEMBL267548 | MLS001074731 | PROTOPORPHYRIN IX | SMR000127405 | cid_4971
Type:
Small organic molecule
Emp. Form.:
C34H34N4O4
Mol. Mass.:
562.6582
SMILES:
Cc1c(CCC(O)=O)c2cc3nc(cc4[nH]c(cc5[nH]c(cc1n2)c(C)c5C=C)c(C)c4C=C)c(C)c3CCC(O)=O
Structure:
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