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TargetCytochrome P450 2D6 (2D6)
LigandBDBM26261
Substrate/CompetitorUS9278914, AMMC
Meas. Tech.In Vitro CYP Inhibition Assay
Temperature310.15±n/a K
IC50 1.77e+4± 0 nM
Commentsextracted
Citation Dalton, JTMiller, DDKearbey, JD SARMs and method of use thereof US Patent US9278914 Publication Date 3/8/2016
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2D6 (2D6)
Name:Cytochrome P450 2D6
Synonyms:CYPIID6 | Cytochrome P450 2D6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:Protein
Mol. Mass.:55774.82
Organism:Homo sapiens (Human)
Description:P10635
Residue:497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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BDBM26261
NameBDBM26261
Synonyms:(2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide | C-31 | CHEMBL512283 | US9278914, S-II
TypeSmall organic molecule
Emp. Form.C18H13ClF4N2O3
Mol. Mass.416.754
SMILESC[C@](O)(COc1ccc(Cl)c(F)c1)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F |r|
Structure
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US9278914, AMMC
NameBDBM189324
Synonyms:US9173935, AMMC
TypeSubstrate
Emp. Form.C18H26NO3
Mol. Mass.304.4034
SMILESCC[N+](C)(CC)CCc1c(C)c2ccc(OC)cc2oc1=O
Structure
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