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Target
Fatty acid-binding protein 5
Ligand
BDBM212451
Substrate
n/a
Meas. Tech.
Time Resolved-Fluorescence Energy Transfer (TR-FRET) Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
19560±n/a nM
Comments
extracted
Citation
 Buettelmann, B; Ceccarelli, SM; Conte, A; Kuehne, H; Kuhn, B; Neidhart, W; Obst Sander, U; Richter, H Urea derivatives and their use as fatty-acid binding protein (FABP) inhibitors US Patent  US9278918 Publication Date 3/8/2016 
Target
Name:
Fatty acid-binding protein 5
Synonyms:
FABP5 | FABP5_HUMAN | Fatty acid binding protein epidermal | Fatty acid-binding protein 5 (FABP5)
Type:
Enzyme
Mol. Mass.:
15164.79
Organism:
Homo sapiens (Human)
Description:
Q01469
Residue:
135
Sequence:
MATVQQLEGRWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCIITCDGKNLTIKTESTLKTTQFSCTLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLKDGKLVVECVMNNVTCTRIYEKVE
  
Inhibitor
Name:
BDBM212451
Synonyms:
US9278918, 41
Type:
Small organic molecule
Emp. Form.:
C19H18ClFN2O3
Mol. Mass.:
376.809
SMILES:
OC(=O)C1(CCCC1)NC(=O)Nc1cc(Cl)ccc1-c1ccc(F)cc1
Structure:
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