Reaction Details Report a problem with these data
Target
Egl nine homolog 1 [179-426]
Ligand
BDBM102345
Substrate
n/a
Meas. Tech.
Activity Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
4400±n/a nM
Comments
extracted
Citation
 Shalwitz, R; Gardner, JH Methods for increasing the stabilization of hypoxia inducible factor-α US Patent  US9278930 Publication Date 3/8/2016 
Target
Name:
Egl nine homolog 1 [179-426]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Hypoxia-inducible factor prolyl hydroxylase 2 (HIFPH2)
Type:
n/a
Mol. Mass.:
27759.84
Organism:
Homo sapiens (Human)
Description:
EGLN-1-179/426
Residue:
248
Sequence:
LRPNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKPSDSVGKDVF
  
Inhibitor
Name:
BDBM102345
Synonyms:
US10562854, No. D10 | US8536181, D10 | US9278930, D10
Type:
Small organic molecule
Emp. Form.:
C23H31N3O4S
Mol. Mass.:
445.575
SMILES:
Cc1ccc(cc1)S(=O)(=O)n1ccc(CN2CCC(CC2)N2CCCCC2)c(O)c1=O
Structure:
Search PDB for entries with ligand similarity: