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TargetAcetyl-CoA carboxylase 2 (ACC2)
LigandBDBM212754
Substrate/Competitorn/a
Meas. Tech.Spectrophotometric 384 Well Assay
pH7.5±n/a
IC50 43±n/a nM
Commentsextracted
Citation Heine, NFleck, MNosse, BRoth, GJ Pyrrolidine derivatives, pharmaceutical compositions and uses thereof US Patent US9278954 Publication Date 3/8/2016
More Info.:Get all data from this article,  Assay Method
 
Acetyl-CoA carboxylase 2 (ACC2)
Name:Acetyl-CoA carboxylase 2 (ACC2)
Synonyms:n/a
Type:Enzyme
Mol. Mass.:92599.28
Organism:Homo sapiens (Human)
Description:O00763 lacks the 128 amino acids at the N-terminus
Residue:839
Sequence:
DTNGLSSSARPQGQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSSDEDSVAGSSREST
RKGSRASLGALSLEAYLTTGEAETRVPTMRPSMSGLHLVKRGREHKKLDLHRDFTVASPA
EFVTRFGGDRVIEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVTPEDLKANA
EYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKLPELLCKNG
VAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGKRISVPEDV
YDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSP
IFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFME
QCAIRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIA
MGVPLHRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDEGFKPSSGT
VQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRG
DFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGALNVADAMFR
TCMTDFLHSLERGQVLPADSLLNLVDVELIYGGVKYILKVARQSLTMFVLIMNGCHIEID
AHRLNDGGLLLSYNGNSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSPSAGKLTQY
TVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVARLELDDPS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM212754
NameBDBM212754
Synonyms:US9278954, 6.8 isomer 1 | US9278954, 6.8 isomer 2 | US9278954, 7.34
TypeSmall organic molecule
Emp. Form.C24H32N2O3
Mol. Mass.396.5225
SMILESCCCOc1ccc(cc1)N1CC[C@H](C1)Oc1ccc(cc1)C(C)C(=O)NCC |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a