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Target
Leukotriene A-4 hydrolase
Ligand
BDBM289905
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
2.40±n/a nM
Comments
extracted
Citation
 Abeywardane, A; Broadwater, J; Brunette, SR; Kirrane, Jr., TM; Razavi, H; Sibley, R; Smith Keenan, LL; Zhang, Q Inhibitors of leukotriene production US Patent  US9573957 Publication Date 2/21/2017 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM289905
Synonyms:
(R)-1-{6-[5-(2H-pyrazol-3-yl)-pyrimidin-2-yloxy]-naphthalen-2-ylmethyl}-pyrrolidin-3-ol (45) | US9573957, Example 45
Type:
Small organic molecule
Emp. Form.:
C22H21N5O2
Mol. Mass.:
387.4344
SMILES:
O[C@@H]1CCN(Cc2ccc3cc(Oc4ncc(cn4)-c4ccn[nH]4)ccc3c2)C1 |r|
Structure:
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