Reaction Details Report a problem with these data
Target
Leukotriene A-4 hydrolase
Ligand
BDBM289932
Substrate
n/a
Meas. Tech.
Enzymatic Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
0.470±n/a nM
Comments
extracted
Citation
Abeywardane, A; Broadwater, J; Brunette, SR; Kirrane, Jr., TM; Razavi, H; Sibley, R; Smith Keenan, LL; Zhang, Q Inhibitors of leukotriene production US Patent US9573957 Publication Date 2/21/2017
More Info.:
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
Inhibitor
Name:
BDBM289932
Synonyms:
1-[1-(2-{6-[5-(2H-Pyrazol-3-yl)- pyridin-2-yloxy]-benzofuran-3-yl}- ethyl)-piperidin-4-yl]-pyrrolidin- 2-one | US9573957, Example 72
Type:
Small organic molecule
Emp. Form.:
C27H29N5O3
Mol. Mass.:
471.5509
SMILES:
O=C1CCCN1C1CCN(CCc2coc3cc(Oc4ccc(cn4)-c4ccn[nH]4)ccc23)CC1