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Target
Dimer of Prostaglandin G/H synthase 2 [R120Q]
Ligand
BDBM209868
Substrate
n/a
Meas. Tech.
POX Assay
pH
8±n/a
Kd
2.2e+2± 1e+1 nM
Comments
extracted
Citation
 Dong, L; Sharma, NP; Jurban, BJ; Smith, WL Pre-existent asymmetry in the human cyclooxygenase-2 sequence homodimer. J Biol Chem 288:28641-55 (2013) [PubMed]  Article 
Target
Name:
Dimer of Prostaglandin G/H synthase 2 [R120Q]
Synonyms:
His8-R120Q/His8-R120Q
Type:
Enzyme
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Prostaglandin G/H synthase 2 [R120Q]
Synonyms:
COX2 | PGH2_HUMAN | PTGS2 | Prostaglandin endoperoxide H synthase-2 (His8-R120Q)
Type:
Enzyme
Mol. Mass.:
70075.97
Organism:
Homo sapiens (Human)
Description:
Human PGHS-2 R120Q mutant with an octahistidine tag at the N terminus
Residue:
612
Sequence:
HHHHHHHHMLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSQSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL
  
Component 2
Name:
Prostaglandin G/H synthase 2 [R120Q]
Synonyms:
COX2 | PGH2_HUMAN | PTGS2 | Prostaglandin endoperoxide H synthase-2 (His8-R120Q)
Type:
Enzyme
Mol. Mass.:
70075.97
Organism:
Homo sapiens (Human)
Description:
Human PGHS-2 R120Q mutant with an octahistidine tag at the N terminus
Residue:
612
Sequence:
HHHHHHHHMLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSQSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKERSTEL
  
Inhibitor
Name:
BDBM209868
Synonyms:
3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+) | Haemin | Heme
Type:
Small organic molecule
Emp. Form.:
C34H32N4O4
Mol. Mass.:
560.6434
SMILES:
Cc1c(C=C)c2cc3[n-]c(cc4[n-]c(cc5nc(cc1n2)c(C=C)c5C)c(C)c4CCC(O)=O)c(CCC(O)=O)c3C
Structure:
Search PDB for entries with ligand similarity: