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Target
E3 ubiquitin-protein ligase XIAP [241-356]
Ligand
BDBM213407
Substrate
n/a
Meas. Tech.
XIAP BIR3 & cIAP1 BIR3 Binding Assays (DELFIA)
Temperature
298.15±n/a K
IC50
73±n/a nM
Comments
extracted
Citation
 Reiser, U; Madden, J 6-Alkynyl Pyridine US Patent  US9278978 Publication Date 3/8/2016 
Target
Name:
E3 ubiquitin-protein ligase XIAP [241-356]
Synonyms:
API3 | BIR3 domain of X-linked inhibitor of apoptosis protein | BIRC4 | E3 ubiquitin-protein ligase (XIAP-BIR3) | E3 ubiquitin-protein ligase XIAP BIR-3 | E3 ubiquitin-protein ligase XIAP BIR3 | IAP3 | X chromosome-linked inhibitor of apoptosis BIR3 domain (XIAP BIR3) | X-linked inhibitor of apoptosis protein BIR3 domain (XIAP BIR-3) | XIAP | XIAP-BIR3 | XIAP_HUMAN | baculovirus IAP repeat 3 (BIR3) domain of XIAP
Type:
Protein Binding Domain
Mol. Mass.:
13276.62
Organism:
Homo sapiens (Human)
Description:
BIR3 of XIAP: RESIDUES 241-356.
Residue:
116
Sequence:
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKCFHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTT
  
Inhibitor
Name:
BDBM213407
Synonyms:
US9278978, 42
Type:
Small organic molecule
Emp. Form.:
C27H23FN8O
Mol. Mass.:
494.5229
SMILES:
CNC(C)C(=O)Nc1cc(cc(n1)C#Cc1cc(F)c2ncccc2c1)-c1ncnc2c(C)nn(C)c12
Structure:
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