Target
Tyrosine-protein kinase ABL1 [64-515]
Ligand
BDBM213496
Substrate
n/a
Meas. Tech.
Caliper ABL
pH
7.5±n/a
Temperature
303.15±n/a K
IC50
<0.13±n/a nM
Comments
extracted
Citation
 Furet, PGrotzfeld, RMJahnke, WJones, DBManley, PWMarzinzik, APelle, XFSalem, BSchoepfer, JSpieser, EA Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1 US Patent  US9278981 Publication Date 3/8/2016 
Target
Name:
Tyrosine-protein kinase ABL1 [64-515]
Synonyms:
ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 | Tyrosine-protein kinase ABL1 (64-515) | Tyrosine-protein kinase ABL1 (ABL) | Tyrosine-protein kinase ABL1 (ABL1)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51539.77
Organism:
Homo sapiens (Human)
Description:
aa 64-515
Residue:
452
Sequence:
NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGV
  
Inhibitor
Name:
BDBM213496
Synonyms:
US9278981, 88
Type:
Small organic molecule
Emp. Form.:
C23H20ClF3N4O3
Mol. Mass.:
492.878
SMILES:
OC[C@H]1CCN(C1)c1ncc(cc1-c1ccc(Cl)nc1)C(=O)Nc1ccc(OC(F)(F)F)cc1 |r|
Structure:
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