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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM290124
Substrate
n/a
Meas. Tech.
GTP γ35S Binding Assay
pH
7.4±n/a
EC50
14.3±n/a nM
Comments
extracted
Citation
 Heidelbaugh, TM; Cappiello, JR; Nguyen, PX; Gomez, DG Coumarin compounds as receptor modulators with therapeutic utility US Patent  US9572792 Publication Date 2/21/2017 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM290124
Synonyms:
N-{4-[(ethylsulfonyl)amino]-2-methylphenyl}-7-methoxy-2-oxo-8-propyl-2H-chromene-3-carboxamide | US9572792, Compound 49
Type:
Small organic molecule
Emp. Form.:
C21H22N2O6S
Mol. Mass.:
430.474
SMILES:
CCCc1c(OC)ccc2cc(C(=O)Nc3ccc(cc3C)S(N)(=O)=O)c(=O)oc12
Structure:
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