Reaction Details Report a problem with these data
Target
Monocarboxylate transporter 1
Ligand
BDBM50092075
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.43±n/a
Temperature
310.15±n/a K
IC50
64±n/a nM
Comments
extracted
Citation
 Mereddy, VR; Drewes, LR; Alam, MA; Jonnalagadda, SK; Gurrapu, S Therapeutic compounds US Patent  US9296728 Publication Date 3/29/2016 
Target
Name:
Monocarboxylate transporter 1
Synonyms:
MCT 1 | MOT1_RAT | Mct1 | Monocarboxylate transporter 1 | Monocarboxylate transporter 1 (MCT1) | Slc16a1 | Solute carrier family 16 member 1
Type:
Enzyme
Mol. Mass.:
53245.17
Organism:
Rattus norvegicus (Rat)
Description:
P53987
Residue:
494
Sequence:
MPPAIGGPVGYTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLILGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQTVNKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVILIIAGLYLFIGMGINYRLVAKEQKAEEKKRDGKEDETSTDVDEKPKKTMKETQSPAPLQNSSGDPAEEESPV
  
Inhibitor
Name:
BDBM50092075
Synonyms:
CHEMBL3582416 | US9296728, 11
Type:
Small organic molecule
Emp. Form.:
C14H14N2O2
Mol. Mass.:
242.2732
SMILES:
OC(=O)C(=C\c1ccc(cc1)N1CCCC1)\C#N
Structure:
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