Reaction Details Report a problem with these data
Target
Orotate phosphoribosyltransferase
Ligand
BDBM214782
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
8±n/a
Temperature
298.15±n/a K
Ki
300±30 nM
Comments
extracted
Citation
 Zhang, Y; Evans, GB; Clinch, K; Crump, DR; Harris, LD; Fröhlich, RF; Tyler, PC; Hazleton, KZ; Cassera, MB; Schramm, VL Transition state analogues of Plasmodium falciparum and human orotate phosphoribosyltransferases. J Biol Chem 288:34746-54 (2013) [PubMed]  Article 
Target
Name:
Orotate phosphoribosyltransferase
Synonyms:
Orotate phosphoribosyltransferase (PfOPRT)
Type:
Enzyme
Mol. Mass.:
33007.07
Organism:
Plasmodium falciparum
Description:
Q8I3Y0
Residue:
281
Sequence:
MTTIKENEFLCDEEIYKSFVHLKDKICEERKKKELVNNNIDNVNFNDDDDNNYDDDGNSYSSYIKEMKKLLKVVLLKYKALKFGEFILKSKRKSNYFFSSGVLNNIVSSNIICFLLSELILKNKLSFDYLLGASYKGIPMVSLTSHFLFESKKYSNIFYLYDRKEKKEYGDKNVIVGNLDDDDKDILNLKKKTKNNQDEEKKNIIIIDDVFTCGTALTEILAKLKTYEHLKVVAFIVLLNRNEYEINENNQKIYFKDIFEKRVGIPLYSILSYKDDIQSMI
  
Inhibitor
Name:
BDBM214782
Synonyms:
OPRT inhibitor, 5
Type:
Small organic molecule
Emp. Form.:
C11H15N4O5
Mol. Mass.:
283.2601
SMILES:
OC[C@H]1[NH2+][C@@H](Cn2c(cc(=O)[nH]c2=O)C#N)C(O)C1O |r|
Structure:
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