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Target
Diacylglycerol O-acyltransferase 2
Ligand
BDBM215464
Substrate
n/a
Meas. Tech.
In Vitro DGAT2 Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
208±n/a nM
Comments
extracted
Citation
 Ahn, K; Boehm, M; Cabral, S; Carpino, PA; Futatsugi, K; Hepworth, D; Kung, DW; Orr, S; Wang, J Diacylglycerol acyltransferase 2 inhibitors US Patent  US9296745 Publication Date 3/29/2016 
Target
Name:
Diacylglycerol O-acyltransferase 2
Synonyms:
ARAT | Acyl-CoA retinol O-fatty-acyltransferase | DGAT2 | DGAT2_HUMAN | Diacylglycerol O-acyltransferase 2 (DGAT2) | Diglyceride acyltransferase 2 | Retinol O-fatty-acyltransferase
Type:
Multi-pass membrane protein
Mol. Mass.:
43848.90
Organism:
Homo sapiens (Human)
Description:
Q96PD7
Residue:
388
Sequence:
MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRWGTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQQDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN
  
Inhibitor
Name:
BDBM215464
Synonyms:
US9296745, 19
Type:
Small organic molecule
Emp. Form.:
C23H25N7O
Mol. Mass.:
415.4909
SMILES:
O=C([C@@H]1CCCN(C1)c1ccc2nc([nH]c2n1)-c1ccc2nccn2c1)N1CCCC1 |r|
Structure:
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