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TargetNicotinamide phosphoribosyltransferase
LigandBDBM216715
Substrate/Competitorn/a
Meas. Tech.Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Binding Assay
pH7.5±n/a
IC50 1.03±n/a nM
Commentsextracted
Citation Curtin, MLSorensen, BKHeyman, HRClark, RFWoller, KRShah, OJMichaelides, MTse, CVasudevan, AMack, HHansen, TMSweis, RPliushchev, MA NAMPT and rock inhibitors US Patent US9302989 Publication Date 4/5/2016
More Info.:Get all data from this article,  Assay Method
 
Nicotinamide phosphoribosyltransferase
Name:Nicotinamide phosphoribosyltransferase
Synonyms:NAmPRTase | Nicotinamide phosphoribosyltransferase (NAMPT) | Pre-B-cell colony-enhancing factor 1
Type:Enzyme
Mol. Mass.:55524.98
Organism:Homo sapiens (Human)
Description:P43490
Residue:491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
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  Blast E-value cutoff:
BDBM216715
NameBDBM216715
Synonyms:US9302989, 1517
TypeSmall organic molecule
Emp. Form.C24H28N4O2
Mol. Mass.404.5047
SMILESCC(C)(C)C(=O)N1CCC(=CC1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 |c:9|
Structure
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