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TargetNicotinamide phosphoribosyltransferase
LigandBDBM217307
Substrate/Competitorn/a
Meas. Tech.Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Binding Assay
pH7.5±n/a
IC50 0.973±n/a nM
Commentsextracted
Citation Curtin, MLSorensen, BKHeyman, HRClark, RFWoller, KRShah, OJMichaelides, MTse, CVasudevan, AMack, HHansen, TMSweis, RPliushchev, MA NAMPT and rock inhibitors US Patent US9302989 Publication Date 4/5/2016
More Info.:Get all data from this article,  Assay Method
 
Nicotinamide phosphoribosyltransferase
Name:Nicotinamide phosphoribosyltransferase
Synonyms:NAmPRTase | Nicotinamide phosphoribosyltransferase (NAMPT) | Pre-B-cell colony-enhancing factor 1
Type:Enzyme
Mol. Mass.:55524.98
Organism:Homo sapiens (Human)
Description:P43490
Residue:491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM217307
NameBDBM217307
Synonyms:US9302989, 1548
TypeSmall organic molecule
Emp. Form.C24H30N4O2
Mol. Mass.406.5206
SMILESCC(C)C(=O)N[C@H]1CC[C@H](CC1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 |wU:6.5,9.12,(-8.88,-1.64,;-8.11,-.31,;-8.88,1.02,;-6.57,-.31,;-5.8,-1.64,;-5.8,1.02,;-4.26,1.02,;-3.49,2.36,;-1.95,2.36,;-1.18,1.02,;-1.95,-.31,;-3.49,-.31,;.36,1.02,;1.13,-.31,;2.67,-.31,;3.44,1.02,;4.98,1.02,;5.75,2.36,;4.98,3.69,;7.29,2.36,;8.2,3.6,;9.66,3.13,;10.99,3.9,;12.33,3.13,;12.33,1.59,;10.99,.82,;9.66,1.59,;8.2,1.11,;2.67,2.36,;1.13,2.36,)|
Structure
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