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TargetNicotinamide phosphoribosyltransferase
LigandBDBM217311
Substrate/Competitorn/a
Meas. Tech.Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Binding Assay
pH7.5±n/a
IC50 0.86±n/a nM
Commentsextracted
Citation Curtin, MLSorensen, BKHeyman, HRClark, RFWoller, KRShah, OJMichaelides, MTse, CVasudevan, AMack, HHansen, TMSweis, RPliushchev, MA NAMPT and rock inhibitors US Patent US9302989 Publication Date 4/5/2016
More Info.:Get all data from this article,  Assay Method
 
Nicotinamide phosphoribosyltransferase
Name:Nicotinamide phosphoribosyltransferase
Synonyms:NAmPRTase | Nicotinamide phosphoribosyltransferase (NAMPT) | Pre-B-cell colony-enhancing factor 1
Type:Enzyme
Mol. Mass.:55524.98
Organism:Homo sapiens (Human)
Description:P43490
Residue:491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVP
EGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNA
QLNIELEAAHH
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM217311
NameBDBM217311
Synonyms:US9302989, 1552
TypeSmall organic molecule
Emp. Form.C25H30N4O2
Mol. Mass.418.5313
SMILESO=C(CC1CC1)N[C@H]1CC[C@H](CC1)c1ccc(NC(=O)N2Cc3ccncc3C2)cc1 |wU:7.7,10.14,(-5.33,2.9,;-6.1,1.56,;-7.64,1.56,;-8.41,2.9,;-9.75,3.67,;-8.41,4.44,;-5.33,.23,;-3.79,.23,;-3.02,1.56,;-1.48,1.56,;-.71,.23,;-1.48,-1.11,;-3.02,-1.11,;.83,.23,;1.6,-1.11,;3.14,-1.11,;3.91,.23,;5.45,.23,;6.22,1.56,;5.45,2.9,;7.76,1.56,;8.66,2.81,;10.13,2.33,;11.46,3.1,;12.79,2.33,;12.79,.79,;11.46,.02,;10.13,.79,;8.66,.32,;3.14,1.56,;1.6,1.56,)|
Structure
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