Reaction Details Report a problem with these data
Target
Myeloperoxidase
Ligand
BDBM217356
Substrate
n/a
Meas. Tech.
Myeloperoxidase Assay
pH
6.5±n/a
IC50
7.9e+2± 1e+1 nM
Comments
extracted
Citation
 Forbes, LV; Sjögren, T; Auchère, F; Jenkins, DW; Thong, B; Laughton, D; Hemsley, P; Pairaudeau, G; Turner, R; Eriksson, H; Unitt, JF; Kettle, AJ Potent reversible inhibition of myeloperoxidase by aromatic hydroxamates. J Biol Chem 288:36636-47 (2013) [PubMed]  Article 
Target
Name:
Myeloperoxidase
Synonyms:
84 kDa myeloperoxidase | 89 kDa myeloperoxidase | MPO | Mpo protein | Myeloperoxidase | Myeloperoxidase (MPO) | Myeloperoxidase heavy chain | Myeloperoxidase light chain | PERM_HUMAN
Type:
Enzyme
Mol. Mass.:
83888.32
Organism:
Homo sapiens (Human)
Description:
P05164
Residue:
745
Sequence:
MGVPFFSSLRCMVDLGPCWAGGLTAEMKLLLALAGLLAILATPQPSEGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRESIKQRLRSGSASPMELLSYFKQPVAATRTAVRAADYLHVALDLLERKLRSLWRRPFNVTDVLTPAQLNVLSKSSGCAYQDVGVTCPEQDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKRNGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEPAARASFVTGVNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPALNLASWREAS
  
Inhibitor
Name:
BDBM217356
Synonyms:
2-(benzylamino)-6-oxo-3H-pyrimidine-5-carbohydroxamic acid (HX3)
Type:
Small organic molecule
Emp. Form.:
C12H12N4O3
Mol. Mass.:
260.2487
SMILES:
ONC(=O)c1c[nH]c(NCc2ccccc2)nc1=O
Structure:
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