Reaction Details Report a problem with these data
Target
Plasminogen [101-181]
Ligand
BDBM290307
Substrate
n/a
Meas. Tech.
Biacore Assay
pH
7±n/a
IC50
14.0±n/a nM
Comments
extracted
Citation
 Haßfeld, J; Kinzel, T; Köbberling, J; Cancho-Grande, Y; Beyer, K; Röhrig, S; Köllnberger, M; Sperzel, M; Burkhardt, N; Schlemmer, K; Stegmann, C; Schuhmacher, J; Werner, M; Ellermann, M (Aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use US Patent  US10098883 Publication Date 10/16/2018 
Target
Name:
Plasminogen [101-181]
Synonyms:
PLG | PLMN_HUMAN | Plasminogen (aa 101-181)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
9281.08
Organism:
Homo sapiens (Human)
Description:
P00747[101-181]
Residue:
81
Sequence:
SECKTGNGKNYRGTMSKTKNGITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILEC
  
Inhibitor
Name:
BDBM290307
Synonyms:
(−)-trans-10-Bromo-4-(2-methylpiperidin-4-yl)pyrimido[1,2-b]indazol-2(1H)-one hydrochloride | US10098883, Example 50 | US10668071, Example 50
Type:
Small organic molecule
Emp. Form.:
C16H17BrN4O
Mol. Mass.:
361.236
SMILES:
CC1CC(CCN1)c1cc(=O)[nH]c2c3c(Br)cccc3nn12
Structure:
Search PDB for entries with ligand similarity: