Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM218176
Substrate
n/a
Meas. Tech.
HDAC Activity Assay
pH
8±n/a
IC50
422±44 nM
Comments
extracted
Citation
 Kozikowski, A; Kalin, JH; Butler, KV; Bergman, J; Hancock, WW HDAC inhibitors and therapeutic methods using the same US Patent  US9249087 Publication Date 2/2/2016 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM218176
Synonyms:
US9249087, 19
Type:
Small organic molecule
Emp. Form.:
C20H23N3O2
Mol. Mass.:
337.4155
SMILES:
CN(C)CCc1cn(Cc2ccc(cc2)C(=O)NO)c2ccccc12
Structure:
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