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Target
Potassium channel subfamily K member 3
Ligand
BDBM218337
Substrate
n/a
Meas. Tech.
TASK-1 Inhibiition Assay
Temperature
298.15±n/a K
IC50
65±n/a nM
Comments
extracted
Citation
 Bialy, L; Lorenz, K; Wirth, K; Steinmeyer, K; Hessler, G Fused pyrroledicarboxamides and their use as pharmaceuticals US Patent  US9284333 Publication Date 3/15/2016 
Target
Name:
Potassium channel subfamily K member 3
Synonyms:
Acid-sensitive potassium channel TASK-1 | Acid-sensitive potassium channel protein TASK-1 | KCNK3 | KCNK3_HUMAN | Potassium channel protein TASK-1 | Potassium channel subfamily K member 3 | Potassium channel subfamily K member 3 (TASK-1) | TASK | TASK1 | TWIK-related acid-sensitive K(+) channel 1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1
Type:
Protein
Mol. Mass.:
43534.71
Organism:
Homo sapiens (Human)
Description:
O14649
Residue:
394
Sequence:
MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
  
Inhibitor
Name:
BDBM218337
Synonyms:
US9284333, 16cc | US9884860, Example 16cc
Type:
Small organic molecule
Emp. Form.:
C23H26ClF3N4O3
Mol. Mass.:
498.926
SMILES:
CC[C@@H](NC(=O)c1cc(C(=O)N2CCC[C@@H]2C)n2CCOCc12)c1ccc(nc1Cl)C(F)(F)F |r|
Structure:
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