Reaction Details Report a problem with these data
Target
S-methyl-5'-thioinosine phosphorylase
Ligand
BDBM50246594
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
0.72±0.03 nM
Comments
extracted
Citation
 Schramm, VL; Clinch, K; Tyler, PC; Evans, GB; Furneaux, RH Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase US Patent  US9290501 Publication Date 3/22/2016 
Target
Name:
S-methyl-5'-thioinosine phosphorylase
Synonyms:
MTIP_PSEAE | S-methyl-5'-thioinosine phosphorylase (MTIP)
Type:
Enzyme
Mol. Mass.:
26266.70
Organism:
Pseudomonas aeruginosa
Description:
Q9HZK1
Residue:
245
Sequence:
MSVYAIIGGTGLTQLEGLTLSESLPIETPYGAPSAPLQRGRYAGREVLFLARHGHPHRFPPHQVNYRANLWALKQAGAEAVIAVNAVGGIHAAMGTGHLCVPHQLIDYTSGREHTYFAGDIEHVTHIDFSHPYDEPLRQRLIEALRALGLAHSSHGVYACTQGPRLETVAEIARLERDGNDIVGMTGMPEAALARELDLPYACLALVVNPAAGKSAGIITMAEIEQALHDGIGKVREVLARVLAG
  
Inhibitor
Name:
BDBM50246594
Synonyms:
(+/-)-7-((1-hydroxy-3-(methylthio)propan-2-ylamino)methyl)-3H-pyrrolo[3,2-d]pyrimidin-4(5H)-one | CHEMBL462398 | US9290501, MT-SerMe-ImmH
Type:
Small organic molecule
Emp. Form.:
C11H16N4O2S
Mol. Mass.:
268.335
SMILES:
CSCC(CO)NCc1c[nH]c2c1nc[nH]c2=O
Structure:
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