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Target
Nuclear receptor ROR-gamma
Ligand
BDBM218787
Substrate
n/a
Meas. Tech.
In vitro RORc Ligand Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
169±n/a nM
Comments
extracted
Citation
 Fauber, B; Rene, O; Bodil van Niel, M; Ward, S Benzyl sulfonamide derivatives as RORc modulators US Patent  US9302985 Publication Date 4/5/2016 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM218787
Synonyms:
US9302985, 17
Type:
Small organic molecule
Emp. Form.:
C23H25ClN2O4S2
Mol. Mass.:
493.039
SMILES:
CC(C)CN(c1cccc(Cl)c1)S(=O)(=O)c1ccc(cc1)-c1ccc(NS(C)(=O)=O)cc1
Structure:
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