Reaction Details Report a problem with these data
Target
Metabotropic glutamate receptor 2
Ligand
BDBM160793
Substrate
n/a
Meas. Tech.
MGluR2 cAMP Assay
pH
7±n/a
EC50
733±n/a nM
Comments
extracted
Citation
Mattson, RJ; Meng, Z; Guernon, LR Positive allosteric modulators of mGluR2 US Patent US9682980 Publication Date 6/20/2017
More Info.:
Target
Name:
Metabotropic glutamate receptor 2
Synonyms:
GPRC1B | GRM2 | GRM2_HUMAN | MGLUR2 | Metabotropic glutamate receptor | glutamate receptor, metabotropic 2 precursor | mGlu2 | metabotropic glutamate 2
Type:
Enzyme
Mol. Mass.:
95584.88
Organism:
Homo sapiens (Human)
Description:
Q14416
Residue:
872
Sequence:
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
Inhibitor
Name:
BDBM160793
Synonyms:
US9682980, 8-Chloro-N-(4-phenylcyclohexyl)-3-(2,2,2-trifluoroethyl)-[1,2,4]triazolo[4,3-b]pyridazin-7-amine
Type:
Small organic molecule
Emp. Form.:
C19H19ClF3N5
Mol. Mass.:
409.836
SMILES:
FC(F)(F)Cc1nnc2c(Cl)c(NC3CCC(CC3)c3ccccc3)cnn12 |(6.58,-1.96,;8.11,-2.12,;8.74,-3.53,;9.64,-2.28,;9.02,-.88,;8.54,.59,;9.44,1.83,;8.54,3.07,;7.08,2.6,;5.75,3.37,;5.75,4.91,;4.41,2.6,;3.08,3.37,;1.75,2.6,;.41,3.37,;-.92,2.6,;-.92,1.06,;.41,.29,;1.75,1.06,;-2.25,.29,;-3.59,1.06,;-4.92,.29,;-4.92,-1.25,;-3.59,-2.02,;-2.25,-1.25,;4.41,1.06,;5.75,.29,;7.08,1.06,)|