Reaction Details Report a problem with these data
Target
Protein kinase C zeta type
Ligand
BDBM218804
Substrate
n/a
Meas. Tech.
PKC AlphaScreen Assay
pH
7.4±n/a
IC50
4.41e+4± 6.3e+3 nM
Comments
extracted
Citation
 Arencibia, JM; Fröhner, W; Krupa, M; Pastor-Flores, D; Merker, P; Oellerich, T; Neimanis, S; Schmithals, C; Köberle, V; Süß, E; Zeuzem, S; Stark, H; Piiper, A; Odadzic, D; Schulze, JO; Biondi, RM An Allosteric Inhibitor Scaffold Targeting the PIF-Pocket of Atypical Protein Kinase C Isoforms. ACS Chem Biol 12:564-573 (2017) [PubMed]  Article 
Target
Name:
Protein kinase C zeta type
Synonyms:
KPCZ_HUMAN | PKC2 | PRKCZ | Protein Kinase C, zeta | Protein kinase C (PKC) | Protein kinase C iota type/zeta type | Protein kinase C zeta | Protein kinase C zeta (PKCζ) | Protein kinase C zeta type | Protein kinase C zeta type (PKC zeta) | Protein kinase C zeta type (PKCzeta) | nPKC-zeta
Type:
Enzyme
Mol. Mass.:
67649.13
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
592
Sequence:
MPSRTGPKMEGSGGRVRLKAHYGGDIFITSVDAATTFEELCEEVRDMCRLHQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLARQCRDEGLIIHVFPSTPEQPGLPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHGLVPLTCRKHMDSVMPSQEPPVDDKNEDADLPSEETDGIAYISSSRKHDSIKDDSEDLKPVIDGMDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQALPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDAIKRIDQSEFEGFEYINPLLLSTEESV
  
Inhibitor
Name:
BDBM218804
Synonyms:
PS312
Type:
Small organic molecule
Emp. Form.:
C20H16ClN3O4
Mol. Mass.:
397.812
SMILES:
CCOC(=O)C1=C(O)C(=O)N(C1c1ccccc1)c1nc2ccc(Cl)cc2[nH]1 |c:5|
Structure:
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