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Target
Aldo-keto reductase family 1 member C1
Ligand
BDBM50000766
Substrate
n/a
Meas. Tech.
Discontinuous Radiometric Assay
IC50
5600±n/a nM
Citation
 Penning, TM; Adeniji, AO; Burns, MC; Winkler, J; Twenter, B Bifunctional AKR1C3 inhibitors/androgen receptor modulators and methods of use thereof US Patent  US9271961 Publication Date 3/1/2016 
Target
Name:
Aldo-keto reductase family 1 member C1
Synonyms:
20-alpha-HSD | 20-alpha-Hydroxysteroid Dehydrogenase (AKR1C1) | AK1C1_HUMAN | AKR1C1 | Aldo-keto reductase family 1 member C1 (AK1C1) | Aldo-keto reductase family 1 member C1 (AK1C1a) | Aldo-keto reductase family 1 member C1 (AKR1C1) | Chlordecone reductase homolog HAKRC | DDH | DDH1 | High-affinity hepatic bile acid-binding protein | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
Type:
Enzyme
Mol. Mass.:
36793.97
Organism:
Homo sapiens (Human)
Description:
Recombinant AKR1C1 enzyme was expressed in E. coli.
Residue:
323
Sequence:
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY
  
Inhibitor
Name:
BDBM50000766
Synonyms:
CHEMBL12 | DIAZEPAM | US9271961, Diazepam
Type:
Small organic molecule
Emp. Form.:
C16H13ClN2O
Mol. Mass.:
284.74
SMILES:
CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1 |c:10|
Structure:
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