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Target
Mu-type opioid receptor
Ligand
BDBM220373
Substrate
n/a
Meas. Tech.
In Vitro Mu-Opioid Receptor Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
Ki
744±55 nM
Comments
extracted
Citation
 Tafesse, L; Tsuno, N; Zhou, X Azetidine-substituted quinoxalines as opioid receptor like-1 modulators US Patent  US9290488 Publication Date 3/22/2016 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM220373
Synonyms:
US9290488, E54a
Type:
Small organic molecule
Emp. Form.:
C31H42N4O3
Mol. Mass.:
518.6902
SMILES:
CC1(C)[C@@H]2C[C@H]1[C@H](CCN1[C@H]3CCC[C@@H]1C[C@@H](C3)n1c3ccccc3nc(N3CC(C3)C(O)=O)c1=O)CC2 |r,THB:8:9:16.17.15:11.13.12|
Structure:
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