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TargetBromodomain-containing protein 4 (BRD4)
LigandBDBM220518
Substrate/Competitorn/a
Meas. Tech.Bromodomain Domain Binding Assay
pH6±n/a
Temperature298.15±n/a K
Ki 0.5±n/a nM
Commentsextracted
Citation Wang, LPratt, JKMcDaniel, KFDai, YFidanze, SDHasvold, LHolms, JHKati, WMLiu, DMantei, RAMcClellan, WJSheppard, GSWada, CK Bromodomain inhibitors US Patent US9296741 Publication Date 3/29/2016
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 (BRD4)
Name:Bromodomain-containing protein 4 (BRD4)
Synonyms:Bromodomain-containing protein 4 (BRD4-BD1)
Type:Enzyme
Mol. Mass.:13496.03
Organism:Homo sapiens (Human)
Description:BD1: amino acids K57-E168 bromodomains of human BRD4
Residue:112
Sequence:
KRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLEN
NYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM220518
NameBDBM220518
Synonyms:US9296741, 107
TypeSmall organic molecule
Emp. Form.C21H22F3N3O5S
Mol. Mass.485.477
SMILESCn1cc(-c2cc(NS(=O)(=O)CC(F)(F)F)ccc2OC2CCCOC2)c2cc[nH]c2c1=O
Structure
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