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TargetBromodomain-containing protein 4 (BRD4)
LigandBDBM220671
Substrate/Competitorn/a
Meas. Tech.Bromodomain Domain Binding Assay
pH6±n/a
Temperature298.15±n/a K
Ki 1±n/a nM
Commentsextracted
Citation Wang, LPratt, JKMcDaniel, KFDai, YFidanze, SDHasvold, LHolms, JHKati, WMLiu, DMantei, RAMcClellan, WJSheppard, GSWada, CK Bromodomain inhibitors US Patent US9296741 Publication Date 3/29/2016
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 (BRD4)
Name:Bromodomain-containing protein 4 (BRD4)
Synonyms:Bromodomain-containing protein 4 (BRD4-BD1)
Type:Enzyme
Mol. Mass.:13496.03
Organism:Homo sapiens (Human)
Description:BD1: amino acids K57-E168 bromodomains of human BRD4
Residue:112
Sequence:
KRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLEN
NYYWNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINELPTEE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM220671
NameBDBM220671
Synonyms:US9296741, 260
TypeSmall organic molecule
Emp. Form.C23H28N2O5S
Mol. Mass.444.544
SMILESCCS(=O)(=O)c1ccc(O[C@H]2CC[C@@H](CC2)OC)c(c1)-c1cn(C)c(=O)c2[nH]ccc12 |wU:10.9,wD:13.16,(5.73,1.29,;6.5,2.62,;5.73,3.95,;4.96,5.29,;7.07,4.72,;4.4,3.18,;3.06,3.95,;1.73,3.18,;1.73,1.64,;.4,.87,;-.94,1.64,;-2.27,.87,;-3.6,1.64,;-3.6,3.18,;-2.27,3.95,;-.94,3.18,;-4.94,3.95,;-6.27,3.18,;3.06,.87,;4.4,1.64,;3.06,-.67,;4.4,-1.44,;4.4,-2.98,;5.73,-3.75,;3.06,-3.75,;3.06,-5.29,;1.73,-2.98,;.27,-3.45,;-.64,-2.21,;.27,-.96,;1.73,-1.44,)|
Structure
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