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Target
Bromodomain-containing protein 4 [352-457]
Ligand
BDBM220490
Substrate
n/a
Meas. Tech.
Bromodomain Domain Binding Assay
pH
6±n/a
Temperature
298.15±n/a K
Ki
1.8±n/a nM
Comments
extracted
Citation
 Wang, L; Pratt, JK; McDaniel, KF; Dai, Y; Fidanze, SD; Hasvold, L; Holms, JH; Kati, WM; Liu, D; Mantei, RA; McClellan, WJ; Sheppard, GS; Wada, CK Bromodomain inhibitors US Patent  US9296741 Publication Date 3/29/2016 
Target
Name:
Bromodomain-containing protein 4 [352-457]
Synonyms:
BRD4 | BRD4_HUMAN | Bromodomain-containing protein 4 (BRD4) | Bromodomain-containing protein 4 (BRD4)(aa 352-457) | Bromodomain-containing protein 4 (BRD4-BD2) | HUNK1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12432.37
Organism:
Homo sapiens (Human)
Description:
BDII: amino acid E352-M457
Residue:
106
Sequence:
EQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKM
  
Inhibitor
Name:
BDBM220490
Synonyms:
US9296741, 79
Type:
Small organic molecule
Emp. Form.:
C28H33N7O5S
Mol. Mass.:
579.671
SMILES:
CN1CCN(CCNC(=O)c2cc3c(nn(C)c(=O)c3[nH]2)-c2cc(NS(C)(=O)=O)ccc2Oc2ccccc2)CC1
Structure:
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