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TargetBromodomain-containing protein 4 (BRD4)
LigandBDBM220492
Substrate/Competitorn/a
Meas. Tech.Bromodomain Domain Binding Assay
pH6±n/a
Temperature298.15±n/a K
Ki 0.99±n/a nM
Commentsextracted
Citation Wang, LPratt, JKMcDaniel, KFDai, YFidanze, SDHasvold, LHolms, JHKati, WMLiu, DMantei, RAMcClellan, WJSheppard, GSWada, CK Bromodomain inhibitors US Patent US9296741 Publication Date 3/29/2016
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 (BRD4)
Name:Bromodomain-containing protein 4 (BRD4)
Synonyms:Bromodomain-containing protein 4 (BRD4-BD2)
Type:Enzyme
Mol. Mass.:12432.37
Organism:Homo sapiens (Human)
Description:BD2: amino acids E352-M457 bromodomains of human BRD4
Residue:106
Sequence:
EQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEARE
YRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM220492
NameBDBM220492
Synonyms:US9296741, 81
TypeSmall organic molecule
Emp. Form.C23H23N5O5S
Mol. Mass.481.524
SMILESCCNC(=O)c1cc2c(nn(C)c(=O)c2[nH]1)-c1cc(NS(C)(=O)=O)ccc1Oc1ccccc1
Structure
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