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TargetBromodomain-containing protein 4 (BRD4)
LigandBDBM220614
Substrate/Competitorn/a
Meas. Tech.Bromodomain Domain Binding Assay
pH6±n/a
Temperature298.15±n/a K
Ki 0.75±n/a nM
Commentsextracted
Citation Wang, LPratt, JKMcDaniel, KFDai, YFidanze, SDHasvold, LHolms, JHKati, WMLiu, DMantei, RAMcClellan, WJSheppard, GSWada, CK Bromodomain inhibitors US Patent US9296741 Publication Date 3/29/2016
More Info.:Get all data from this article,  Assay Method
 
Bromodomain-containing protein 4 (BRD4)
Name:Bromodomain-containing protein 4 (BRD4)
Synonyms:Bromodomain-containing protein 4 (BRD4-BD2)
Type:Enzyme
Mol. Mass.:12432.37
Organism:Homo sapiens (Human)
Description:BD2: amino acids E352-M457 bromodomains of human BRD4
Residue:106
Sequence:
EQLKCCSGILKEMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMSTIKSKLEARE
YRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM220614
NameBDBM220614
Synonyms:US9296741, 203
TypeSmall organic molecule
Emp. Form.C22H26N2O5S
Mol. Mass.430.517
SMILESCCS(=O)(=O)c1ccc(O[C@H]2CC[C@H](O)CC2)c(c1)-c1cn(C)c(=O)c2[nH]ccc12 |wU:10.9,wD:13.13,(5.29,1.39,;6.06,2.73,;5.29,4.06,;4.52,5.39,;6.62,4.83,;3.95,3.29,;2.62,4.06,;1.29,3.29,;1.29,1.75,;-.05,.98,;-1.38,1.75,;-2.71,.98,;-4.05,1.75,;-4.05,3.29,;-5.38,4.06,;-2.71,4.06,;-1.38,3.29,;2.62,.98,;3.95,1.75,;2.62,-.56,;3.95,-1.33,;3.95,-2.87,;5.29,-3.64,;2.62,-3.64,;2.62,-5.18,;1.29,-2.87,;-.18,-3.35,;-1.08,-2.1,;-.18,-.85,;1.29,-1.33,)|
Structure
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