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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50246766
Substrate
US9302986, benzylamine
Meas. Tech.
MAO-B Inhibition Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
5±n/a nM
Comments
extracted
Citation
 Deodhar, M; Findlay, AD; Foot, JS; Jarolimek, W; Mcdonald, IA; Robertson, AD; Turner, CI Substituted 3-haloallylamine inhibitors of ASSAO and uses thereof US Patent  US9302986 Publication Date 4/5/2016 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Homo sapiens (Human)
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50246766
Synonyms:
CHEMBL489079 | Mofegiline | US9302986, Mofegiline
Type:
Small organic molecule
Emp. Form.:
C11H13F2N
Mol. Mass.:
197.2244
SMILES:
NC\C(CCc1ccc(F)cc1)=C\F
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
BDBM10999
Synonyms:
Benzenemethanamine | Bn-NH2 | CHEMBL522 | benzylamine | phenylmethanamine
Type:
Small organic molecule
Emp. Form.:
C7H9N
Mol. Mass.:
107.1531
SMILES:
NCc1ccccc1
Structure:
Search PDB for entries with ligand similarity: