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TargetC-X-C chemokine receptor type 4 (CXCR4)
LigandBDBM221860
Substrate/Competitorn/a
Meas. Tech.Calcium Mobilization Assay
Temperature310.15±n/a K
IC50 1±n/a nM
Commentsextracted
Citation Clark, MPWagner, FFNatchus, MGDoroh, BCJohnson, TLTahirovic, YAWilson, LWiseman, JMSkudlarek, JWLockwood, MA Chemokine receptor modulators US Patent US9314468 Publication Date 4/19/2016
More Info.:Get all data from this article,  Assay Method
 
C-X-C chemokine receptor type 4 (CXCR4)
Name:C-X-C chemokine receptor type 4
Synonyms:C-X-C chemokine receptor type 4 | CD_antigen=CD184 | CXC-R4 | CXCR-4 | FB22 | Fusin | HM89 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor
Type:Enzyme
Mol. Mass.:39754.61
Organism:Homo sapiens (Human)
Description:P61073
Residue:352
Sequence:
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM221860
NameBDBM221860
Synonyms:US9314468, Table 7, Compound 147
TypeSmall organic molecule
Emp. Form.C35H46N6O
Mol. Mass.566.7793
SMILESC(CN(Cc1nccc2c3ccccc3n(CCC3CCOCC3)c12)[C@H]1CCCc2cccnc12)CN1CCNCC1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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