Reaction Details Report a problem with these data
Target
Oligo-1,6-glucosidase IMA1
Ligand
BDBM222071
Substrate
n/a
Meas. Tech.
Baker's Yeast α-Glucosidase Inhibition Assay
pH
6.8±n/a
Temperature
310.15±n/a K
IC50
2.7682e+5± 6.4e+2 nM
Comments
extracted
Citation
 Zawawi, NK; Taha, M; Ahmat, N; Ismail, NH; Wadood, A; Rahim, F Synthesis, molecular docking studies of hybrid benzimidazole as a-glucosidase inhibitor. Bioorg Chem 70:184-191 (2017) [PubMed]  Article 
Target
Name:
Oligo-1,6-glucosidase IMA1
Synonyms:
α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase
Type:
Protein
Mol. Mass.:
68577.59
Organism:
Saccharomyces cerevisiae S288c (Baker's yeast)
Description:
n/a
Residue:
589
Sequence:
MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
  
Inhibitor
Name:
BDBM222071
Synonyms:
2-(4-(5,6-Dimethyl-1H-benzo[d]imidazol-2-yl)benzoyl)-N-(4-fluorophenyl)hydrazinecarbothioamide (12)
Type:
Small organic molecule
Emp. Form.:
C23H20FN5OS
Mol. Mass.:
433.501
SMILES:
Cc1cc2nc([nH]c2cc1C)-c1ccc(cc1)C(=O)NNC(=S)Nc1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: