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Target
Oligo-1,6-glucosidase IMA1
Ligand
BDBM222076
Substrate
n/a
Meas. Tech.
Baker's Yeast α-Glucosidase Inhibition Assay
pH
6.8±n/a
Temperature
310.15±n/a K
IC50
2.9799e+5± 1.20e+3 nM
Comments
extracted
Citation
 Zawawi, NK; Taha, M; Ahmat, N; Ismail, NH; Wadood, A; Rahim, F Synthesis, molecular docking studies of hybrid benzimidazole as a-glucosidase inhibitor. Bioorg Chem 70:184-191 (2017) [PubMed]  Article 
Target
Name:
Oligo-1,6-glucosidase IMA1
Synonyms:
α-glucosidase | Alpha-glucosidase | Alpha-glucosidase (α-glucosidase) | IMA1 | MALX3_YEAST | Oligo-1,6-glucosidase
Type:
Protein
Mol. Mass.:
68577.59
Organism:
Saccharomyces cerevisiae S288c (Baker's yeast)
Description:
n/a
Residue:
589
Sequence:
MTISSAHPETEPKWWKEATFYQIYPASFKDSNDDGWGDMKGIASKLEYIKELGADAIWISPFYDSPQDDMGYDIANYEKVWPTYGTNEDCFALIEKTHKLGMKFITDLVINHCSSEHEWFKESRSSKTNPKRDWFFWRPPKGYDAEGKPIPPNNWKSYFGGSAWTFDEKTQEFYLRLFCSTQPDLNWENEDCRKAIYESAVGYWLDHGVDGFRIDVGSLYSKVVGLPDAPVVDKNSTWQSSDPYTLNGPRIHEFHQEMNQFIRNRVKDGREIMTVGEMQHASDETKRLYTSASRHELSELFNFSHTDVGTSPLFRYNLVPFELKDWKIALAELFRYINGTDCWSTIYLENHDQPRSITRFGDDSPKNRVISGKLLSVLLSALTGTLYVYQGQELGQINFKNWPVEKYEDVEIRNNYNAIKEEHGENSEEMKKFLEAIALISRDHARTPMQWSREEPNAGFSGPSAKPWFYLNDSFREGINVEDEIKDPNSVLNFWKEALKFRKAHKDITVYGYDFEFIDLDNKKLFSFTKKYNNKTLFAALNFSSDATDFKIPNDDSSFKLEFGNYPKKEVDASSRTLKPWEGRIYISE
  
Inhibitor
Name:
BDBM222076
Synonyms:
2-(4-(5,6-Dimethyl-1H-benzo[d]imidazol-2-yl)benzoyl)-N-(p-tolyl)hydrazinecarbothioamide (17)
Type:
Small organic molecule
Emp. Form.:
C24H23N5OS
Mol. Mass.:
429.537
SMILES:
Cc1ccc(NC(=S)NNC(=O)c2ccc(cc2)-c2nc3cc(C)c(C)cc3[nH]2)cc1
Structure:
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