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Reaction Details
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TargetLysophosphatidic acid receptor 1
LigandBDBM251730
Substrate/Competitorn/a
Meas. Tech.In Vitro LPA1 Receptor Assay
Temperature298.15±n/a K
IC50 7.00±n/a nM
Commentsextracted
Citation Buffham, WCanning, HDavenport, RFarnaby, WMack, SParmar, AWright, S Amide derivatives as lysophosphatidic acid receptor antagonists US Patent US10100018 Publication Date 10/16/2018
More Info.:Get all data from this article,  Assay Method
 
Lysophosphatidic acid receptor 1
Name:Lysophosphatidic acid receptor 1
Synonyms:LPA receptor 1 | LPA-1 | LPAR1 | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2
Type:Enzyme
Mol. Mass.:41120.55
Organism:Homo sapiens (Human)
Description:Q92633
Residue:364
Sequence:
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVC
IFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVST
WLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMS
RHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLA
EFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSND
HSVV
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  Blast E-value cutoff:
BDBM251730
NameBDBM251730
Synonyms:US10100018, Example 66 | US9464060, 66
TypeSmall organic molecule
Emp. Form.C26H24FNO5
Mol. Mass.449.4709
SMILESCOc1ccccc1Oc1ccc(C(=O)N(CC2CC2)Cc2ccc(cc2)C(O)=O)c(F)c1
Structure
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