Reaction Details Report a problem with these data
Target
Lysophosphatidic acid receptor 1
Ligand
BDBM251738
Substrate
n/a
Meas. Tech.
In Vitro LPA1 Receptor Assay
Temperature
298.15±n/a K
IC50
40.0±n/a nM
Comments
extracted
Citation
 Buffham, W; Canning, H; Davenport, R; Farnaby, W; Mack, S; Parmar, A; Wright, S Amide derivatives as lysophosphatidic acid receptor antagonists US Patent  US10100018 Publication Date 10/16/2018 
Target
Name:
Lysophosphatidic acid receptor 1
Synonyms:
EDG2 | LPA receptor 1 | LPA-1 | LPA1 | LPAR1 | LPAR1_HUMAN | Lysophosphatidic acid receptor 1 (LPA1) | Lysophosphatidic acid receptor Edg-2
Type:
Enzyme
Mol. Mass.:
41120.55
Organism:
Homo sapiens (Human)
Description:
Q92633
Residue:
364
Sequence:
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
  
Inhibitor
Name:
BDBM251738
Synonyms:
US10100018, Example 74 | US9464060, 74
Type:
Small organic molecule
Emp. Form.:
C24H20F3NO4
Mol. Mass.:
443.4151
SMILES:
CC(F)(F)CN(Cc1ccc(cc1)C(O)=O)C(=O)c1ccc(Oc2ccccc2F)cc1
Structure:
Search PDB for entries with ligand similarity: