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Target
Cytochrome P450 144 [31-434]
Ligand
BDBM24656
Substrate
n/a
Meas. Tech.
Optical Titration Assay
pH
7±n/a
Kd
2.980e+6± 3.00e+5 nM
Comments
extracted
Citation
 Kavanagh, ME; Chenge, J; Zoufir, A; McLean, KJ; Coyne, AG; Bender, A; Munro, AW; Abell, C Fragment Profiling Approach to Inhibitors of the Orphan M. tuberculosis P450 CYP144A1. Biochemistry 56:1559-1572 (2017) [PubMed]  Article 
Target
Name:
Cytochrome P450 144 [31-434]
Synonyms:
CP144_MYCTO | Cytochrome P450 144 (CYP144A1-TRV) | cyp144
Type:
Protein
Mol. Mass.:
43963.64
Organism:
Mycobacterium tuberculosis
Description:
M. tuberculosis cytochrome P450 144 truncation (31-434 aa)
Residue:
404
Sequence:
MTIAKDANTFFGAESVQDPYPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAEGTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWVDGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLVAAGVALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGGESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNATTLDGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALARLEARIVLRLLLDRTSVIEAADVGGWLPSILVRRIERLELAVQ
  
Inhibitor
Name:
BDBM24656
Synonyms:
4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole | 4-phenylimidazole, 4-PI | CHEMBL14145 | US9138393, 4-Phenyl- imidazole | US9144538, 4-Phenylimidazole
Type:
Small organic molecule
Emp. Form.:
C9H8N2
Mol. Mass.:
144.1732
SMILES:
c1nc(c[nH]1)-c1ccccc1
Structure:
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